Despite the widespread belief that HPV infection is a lethal force against which we only have vaccination and watchful waiting to defend ourselves, both ancient herbal medicine and our body's inherent immune defenses have newly been confirmed to have significant power against it.

A groundbreaking study published in the Asian Pacific Journal of Cancer Prevention, titled, "Clearance of Cervical Human Papillomavirus Infection by Topical Application of Curcumin and Curcumin Containing Polyherbal Cream: A Phase II Randomized Controlled Study," reveals that vaccination and watchful waiting are not the only recourse against HPV infection.  

The study is believed to be the first of its kind to find an effective and safe therapeutic intervention for the clearance of established cervical human papillomavirus (HPV) infection. Moreover, the study confirmed that HPV infection is self-limiting and clears on its own in 73.3% of the untreated placebo group within 37 days. 

The researchers evaluated the effectiveness of two herbal interventions in eliminating HPV infection from the cervix of women who were determined to have HPV infection through Pap smear and HPV DNA tests (PCR), but whose condition had not yet progressed to high grade cervical neoplasias (i.e. cervical pre-cancer).

The first intervention used was a polyherbal vaginal cream containing containing extracts of curcumin, reetha, amla and aloe vera, known by the trade name Basant. The second intervention was a curcumin vaginal capsule. The other two placebo groups received either a vaginal placebo cream or a placebo vaginal capsule.  

All 287 subjects were instructed to use one application of the assigned formulation daily for 30 consecutive days except during menstruation. Seven days after the last application they were recalled for repeat HPV test, cytology and colposcopy.

The results were reported as follows:

"HPV clearance rate in Basant arm (87.7%) was significantly higher than the combined placebo arms (73.3%). Curcumin caused higher rate of clearance (81.3%) than placebo though the difference was not statistically significant."

Vaginal irritation and itching, mostly mild to moderate, was significantly higher after Basant application. No serious adverse events were noted.

While both of the herbal formulations clearly increased the rate of HPV clearance, it is noteworthy that the placebo group also experienced a 73.3% clearance rate, as it confirms that majority of HPV infections will clear from the body as a result of the immune system doing its job correctly. The researchers acknowledged that this is not a novel finding:

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